RESEARCH
I recently participated in the creation of a new multidisciplinary research lab since 01/01/2012 with a major thematic reconversion, but based on my skill in physical-chemistry. This new lab includes physicists modeling, opticians, physico-chemists, chemists in galenics and hospital practitioners (medical imaging and pediatric surgery mainly) to open on nanomedicine (noted A globally and A + in research, following the visit of the HCERES committee). I am engaged in collaborative programs that relate to emerging nanomedicine and clustered in what is called theranostic.
More broadly, during my 20 years of research as an assitant professor at the University of Bourgogne Franche-Comté in Besançon, in an original way, I attached myself :
to elucidate new (electrochemical) polymerization reactions. I have discovered and published that the aliphatic molecules bearing two functional groups A and B can be electropolymerized on numerous electrode materials according to the following scheme:
to apply these polymers in a thin layer to different themes: electrical energy storage, thin layer surface functionalization, sensors and biosensors embedded or not in microsystems. The goal is to better discriminate analytes by coupling several techniques in (bio) sensors in (bio) analytical chemistry. I therefore use the skills of the MIMENTO platform, a clean room in the Franche-Comté region, which is one of the RENATECH network technology centers.to model and interpret experimental results by modeling calculations (DFT via Crystal14 or OpenMX-square or jDFTx, protein-protein docking, molecular dynamics via CHARMM force field). I use the high-performance computing center facilities from the Mesocentre of Franche-Comté to model the behavior of molecules on surfaces or trapped in sol-gels matrices for example.
to expand my skills in Nanomedicine in my laboratory. In this capacity, I initiated the nanovectorisation theme of the anti-cancer ligand TRAIL, a cytokine, to efficiently target the receptors of death of malignant cells and cause their apoptosis (in vitro). This work is part now of the new theranostic team, created in our lab for the new evaluation in 2016, January.
During the last 20 years I participated in the publication of 60 peer reviewed articles and 8 patents. My h-index is 17 (source Google Scholar, April 2017). I supervised 14 Ph.D. thesis, one of which is in progress. I was involved in numerous contracts as a specialist of physical-chemistry, which have helped to attract more than 1.5 million euros.
